Chemistry

Carrick Research Group

Carrick Research Group 2024

Dr. Carrick
Jesse D. Carrick, Ph.D.

Professor
Department of Chemistry
TN Tech University
Campus Box 5055
803 Stadium Dr.
Lab Science Commons, Rm 3304
Cookeville, TN 38505-0001

P: (931) 372-6199
E: jcarrick@tntech.edu
Education
- A.S. 2000 Motlow State Community College
- B.S. 2002 Middle TN State University (Prof. Norma K. Dunlap)
- M.S. 2005 Indiana University-Bloomington (Prof. David R. Williams)
- Ph.D. 2008 The University of Alabama (Prof. Michael P. Jennings)
Dr. Carrick's Curriculum Vitae

Bio

Jesse D. Carrick was born in Murfreesboro, TN and spent his formative years on the family farm near Shelbyville, TN. He attended Cascade High School, Wartrace, TN and graduated with an Honors diploma in 1998. Carrick attended Motlow State Community College and graduated with an A.S. in 2000. He was introduced to the art and science of chemical synthesis as an undergraduate student at Middle Tennessee State University with Prof. Norma K. Dunlap earning an ACS-certified B.S. in chemistry in 2002. Carrick then relocated to Indiana University, Bloomington where he contributed to efforts toward the total synthesis of the marine natural product amphidinolide C in the laboratory of Prof. David R. Williams, earning his M.S. in 2005. Carrick completed his doctoral work at The University of Alabama in 2008 under the direction of Prof. Michael P. Jennings where he accomplished a formal synthesis of the marine natural product (−)-clavosolide a.

He obtained professional experience as a Senior Research Scientist in chemical development (process) at Albany Molecular Research Inc., in Albany, NY from 2009-10 and returned to academia as a Visiting Assistant Professor of Chemistry at Union College, Schenectady, NY (2010-11) where he initiated research in the area of organic synthesis with undergraduates.

Carrick accepted a tenure-track appointment as an Assistant Professor in the Department of Chemistry at Tennessee Technological University, Cookeville, TN in 2011, was tenured and promoted to Associate Professor in 2016, and promoted to Professor in 2021. Research in the Carrick group is currently focused in two distinct, but complementary student-training areas: Synthesis of heterocyclic complexants for chemoselective minor actinide separations, and Total synthesis of biologically relevant natural products.

When not in the lab he enjoys studying American history, fishing, gardening, and drag racing.
Publications

31. Fletcher, L. S.; Tedder, M. L.; Olayiwola, S. O.; Carrick, J. D.* A Hydrolytically Stable Complexant for Minor An Separation from Ln in Process Relevant Diluents. Chemical Communications 2024, 60, 5642–5645. View Article

30. Edirin, O. J.; Carrick, J. D.* Synthesis of Fused [1,2,3]-Triazoloheteroarenes via Intramolecular Azo Annulation of N-Tosylhydrazones Catalyzed by 1,8-Diazabicyclo[5.4.0]undec-7-ene. Journal of Organic Chemistry 2024, 89, 7201–7209. View Article

29. Tedder, M. L.; Carrick, J. D.* A Synthetic Strategy for the Preparation of Alkoxy-Functionalized Bis-1,2,4-triazinyl-pyridines. Journal of Heterocyclic Chemistry 2024, Early View. View Article

28. Fletcher, L. S.; Tedder, M. L.; Olayiwola, S. O.; Joyner, N. A.; Mason, M. M.; Oliver, A. G.; Ensor, D. D.; Dixon, D. A.; Carrick, J. D.* Next Generation 3,3’-AlkoxyBTPs as Complexants for Minor Actinide Separation from Lanthanides: A Comprehensive Separations, Spectroscopic, and DFT Study. Inorganic Chemistry 2024, 63, 4819–4827. View Article

27. Agyei, E. A.; Carrick, J. D.* Synthetic Approach to the Construction of Unsymmetric Pyridyl-1,2,4-Triazine Complexants. Tetrahedron 2024, 155, 133872. DOI: View Article

26. Fletcher, L. S.; Tedder, M. L.; Olayiwola, S. O.; Ensor, D. D.; Carrick, J. D.* Separation of 241Am3+ from 154Eu3+ from Simulated Spent Nuclear Fuel in Trifluoromethylphenyl Sulfone using 3,3’-butyloxy-bis-1,2,4-triazinyl-2,6-pyridine as a Potent Receptor. Solvent Extraction and Ion Exchange 2024, 42, 105–117. View Article

25. Agyei, E. A. and Carrick, J. D.* Metal-Free, Oxidative Condensation of Heteroaryl- and Aryl Carbaldehydes towards Functionalized Carbonitriles. Chemistry Select 2023, 8, e202300866. View Article

24. Xiao, Z.; Liu, J.; Liu, K.; Petridis, L.; Cai, C.; Cao, L.; Wang, G.; Chin, A.-L.; Cleveland, J. W.; Ikedionwu, M. O.; Carrick, J. D.; Smith, J. C.; Quarles, L. D.* Small Molecule FGF23 Inhibitors Increase Serum Phosphate and Improve Skeletal Abnormalities in Hyp Mice. Molecular Pharmacology 2022, 101, 408–421. View Article

23. Tedder, M. L.; Dzeagu, F. O.; Mason, M. M.; Dixon, D. A.; Carrick, J. D.* Microwave-Assisted C-H Oxidation of Methylpyridylheteroarenes via a Kornblum-type Reaction. Tetrahedron 2022, 116, 132805, DOI: View Article

22. Gulledge, Z. Z.; Duda, D. P.; Dixon, D. A.; Carrick, J. D.* Microwave-Assisted, Metal- and Azide-Free Synthesis of Functionalized Heteroaryl-1,2,3-triazoles via Oxidative Cyclization of N-Tosylhydrazones and Anilines. Journal of Organic Chemistry 2022, 87, 12632–12643, View Article

21. Gulledge, Z. Z.; Pinson, C. C.; Stovall, A. M.; Dzeagu, F. O.; Carrick, J. D.* Chemoselective, Osmium-Free, Dihydroxylation / Oxidative Cleavage of Heteroaryl Isoprenes by a Contemporary Malaprade Reaction. Organic and Biomolecular Chemistry 2022, 20, 7916–7922. View Article

20. Dzeagu, F. O. and Carrick, J. D.* Synthetic Access to Unsymmetric 1,3,4-oxadiazolyl Complexant Scaffolds via Intramolecular Oxidative Annulation of Arylhydrazones with Heteroaryl Carbaldehydes. Journal of Organic Chemistry 2022, ASAP, 12/27/22 View Article

19. Prediction of An(III)/Ln(III) Separation by 1,2,4-Triazinylpyridine Derivatives Marcos M. Mason, Caris Smith, Monica Vasiliu, Jesse D. Carrick, and David A. Dixon The Journal of Physical Chemistry A 2021 125 (30), 6529-6542 View Article

18. Downs, R. P.; Xiao, Z.; Ikedionwu, M. O.; Cleveland, J. W.; Chin, A.-L.; Cafferty, A. E.; Quarles, L. D.; Carrick, J. D.* Design and development of FGF-23 antagonists: Definition of the pharmacophore and initial structure-activity relationships probed by synthetic analogues. Bioorganic and Medicinal Chemistry 2021, 29, 115877. DOI: 10.1016/j.bmc.2020.115877. View article.

17. Waters, G. D.; Carrick, J. D. "Convergent access to bis-1,2,4-triazinyl-2,2’-bipyridines (BTBPs) and 2,2’-bipyridines via a Pd-catalyzed Ullman-type reaction." RSC Advances 2020, 10, 10807–10815. View Article

16. Gulledge, Z. Z.; Carrick, J. D.* Chemoselective BOC-deprotection of functionalized heteroarenes using an addition/elimination strategy. European Journal of Organic Chemistry, 2020, 12, 1817–1822. View Article

15. Gulledge, Z. Z.; Tedder, M. L.; Lyons, K. R.; Carrick, J. D.* Synthesis of tridentate indolyl pyridinyl [1,2,4] triazine Lewis basic complexants via Pd-catalyzed Suzuki-Miyaura cross-coupling. ACS Omega, 2019, 4, 18855–18866. View Article

14. Veerakanellore, G. B.; Smith, C. M.; Vasiliu, M.; Oliver, A. G.; Dixon, D. A.; Carrick, J. D.* Synthesis of 1H-pyrazol-5-yl-pyridin-2-yl-[1,2,4]triazinyl soft-Lewis basic complexants via metal and oxidant free [3+2] dipolar cycloaddition of terminal ethynyl pyridines with tosylhydrazides. Journal of Organic Chemistry 2019, 84, 14558–14570. View Article

13. Chaudhuri, S.; Carrick, J. D.* Synthetic access to functionalized dipolarophiles of Lewis Basic Complexant Scaffolds through Sonogashira Cross-Coupling. Journal of Organic Chemistry 2018, 83, 10261−10271, View Article

12. Smith, C. D.; Downs, R. P.; Carrick, J. D.; Dietz, M. L.* Determination of extractant solubility in ionic liquids by thermogravimetric analysis. Solvent Extraction and Ion Exchange 2018, 36, 304−314. View Article
11. Lambert, A. E.; Carrick, J. D.* Diversification of 6-bromo-2-substituted pyridine derivatives via Suzuki-Miyaura cross-coupling. Journal of Heterocyclic Chemistry 2018, 55, 1232−1239, View Article

10. Hill, T. G.; Chin, A.-L.; Tai, S.; Carrick, J. D.; Ensor, D. D.; Delmau, L. H. Separation of americium from europium using 3,3’-dimethoxy-phenyl-bis-1,2,4-triazinyl-2,6-pyridine. Separation Science and Technology 2018, 53, 1848−1855, View Article

9. Tevepaugh, K. N.; Coonce, J. G.; Tai, S.; Delmau, L. H.; Carrick, J. D.; Ensor, D. D. Chromatographic separation of americium from europium using bis-2,6-(5,6,7,8-tetrahydro-5,9,9-trimethyl-5,8-methano-1,2,4-benzotriazin-3-yl) pyridine. Journal of Radioanalytical and Nuclear Chemistry 2017, 314(1), 371−376. View Article

8. Cleveland, J. W.; Carrick, J. D.* Pd-catalyzed amination of functionalized 6-bromo-pyridinyl-1,2,4-triazine complexant scaffolds. European Journal of Organic Chemistry 2017, 2017(23) 3318−3327. View Article

7. Downs, R. P.; Chin, A.-L.; Dean, K. M.; Carrick, J. D.* Synthesis of functionalized hemi-1,2,4-triazinyl-[2,2’]-bipyridines via telescoped condensation of [2,2']-bipyridinyl-6-carbonitrile. Journal of Heterocyclic Chemistry 2017, 54(6), 3008−3014. View Article

6. Xiao, Z. S.; Riccardi, D.; Velazquez, H. A.; Chin, A.-L.; Yates, C. R.; Carrick, J. D.; Smith, J. C.; Baudry, J.; Quarles, L. D. Computationally identified novel chemical compounds that antagonize FGF-23. Science Signaling 2016, 9(455), ra113-Cover Story. View Article

5. Tai, S.; Marchi, S. V.; Carrick, J. D.* Efficient preparation of pyridinyl-1,2,4-triazines via telescoped condensation with diversely functionalized 1,2-dicarbonyls. Journal of Heterocyclic Chemistry 2016, 53, 1138−1146. View Article

4. Chin, A.-L.; Carrick, J. D.* Modular approaches to diversified soft Lewis basic complexants through Suzuki-Miyaura cross-coupling of bromoheteroarenes with organotrifluoroborates. Journal of Organic Chemistry 2016, 81, 1106−1115. View Article

3. Tevepaugh, K. N.; Carrick, J. D.; Tai, S.; Coonce, J. G.; Delmau, L. H.; Ensor, D. D. Separation of americium from europium using camphor-bistriazinyl pyridine. Solvent Extraction and Ion Exchange 2016, 34, 13−25. View Article

2. Tai. S., Williams, N. J.; Carrick, J. D.* Synthesis of bis-1,2,4-triazines via telescoped condensation of [1,10]-phenanthroline-2,9-dicarbonitrile with aromatic 1,2-dicarbonyls. Journal of Heterocyclic Chemistry 2016, 53, 307−312. View Article

1. Tai, S.; Marchi, S. V.; Dover, E. J.; Carrick, J. D.* Pd-catalyzed diamination of dibromo-1,2,4-triazinyl complexant scaffolds. Journal of Organic Chemistry 2015, 80, 6275−6282. View Article

Current Group Members

Thilakarathne, Lakshi M., EVS Ph.D. student, lmthilakar42@tntech.edu, LSC 3312
Agyei, Eric A. M.S. student, eaagyei42@tntech.edu, LSC 3312
Ajibola, Bolade R. M.S. student, bajibola42@tntech.edu, LSC 3312
Aimiuwu, Emmanuel E., M.S. student, eeaimiuwu42@tntech.edu LSC 3312
Edirin, Orume M.S. student, ojedirin42@tntech.edu, LSC 3312
Jonathan, Victor M.S. student, vcjonathan42@tntech.edu, LSC 3312
Olayiwola, Samiat O. M.S. student, soolayiwol42@tntech.edu, LSC 3312
Buchanan, Anna L., B.S. student, albuchanan42@tntech.edu, LSC 3312
Hudak, C. Blake B.S. student, cbhudak42@tntech.edu, LSC 3312
Wood, Shayla G., B.S. student, sgwood42@tntech.edu, LSC 3312

Teaching

CHEM 6210 Advanced Organic Chemistry
CHEM 3010 Organic Chemistry I
CHEM 3020 Organic Chemistry II

Research Opportunities

The Carrick group currently has open positions for postdoctoral, EVS Ph.D., M.S., and B.S. students for the 2024-2025 academic year. Students with research interests in separation science broadly defined, as well as analytical, inorganic, and organic chemistry are particularly encouraged to contact Dr. Carrick at jcarrick@tntech.edu for additional information.

Carrick Group News

June 2024-Congratulations to Eric for successfully defending his M.S. thesis! Eric will pursue a Ph.D. in chemistry at the University of Florida fall 2024.
June 2024-Congratulations to Orume for successfully defending his M.S. thesis! Orume will begin his Ph.D. studies at the University of Arizona fall 2024.
June 2024-Congratulations to Victor for successfully defending his M.S. thesis! Victor will matriculate to the University of Washington to begin working on his Ph.D. fall 2024.
May 2024-A collaborative project on the preliminary extraction efficacy of 3,3’-dioctyloxy BTP in a kerosene:isooctanol blend has been published in Chem. Commun. https://doi.org/10.1039/D4CC00983E
May 2024-Orume’s project focusing on the construction of fused 1,2,3-pyridyl triazines has been accepted for publication in J. Org. Chem. https://doi.org/10.1021/acs.joc.4c00627
May 2024-Mariah’s project describing a synthetic method for the preparation of symmetric alkoxy-BTPs has been published in J. Heterocycl. Chem. https://doi.org/10.1002/jhet.4828
April 2024-Eric’s project aimed at the synthesis of unsymmetric BTP complexants for separations was published in Tetrahedron https://doi.org/10.1016/j.tet.2024.133872
April 2024-Congratulations to Dr. Fletcher who accepted a staff scientist position at Oak Ridge National lab.
March 2024-A A Comprehensive Separations, Spectroscopic, and DFT Study on 3,3’-butyloxy BTP has been accepted for publication in Inorg. Chem. https://doi.org/10.1021/acs. inorgchem.3c02061
February 2024-Evaluation of 3,3’-butyloxy BTP for 241Am3+ extraction in FS-13 has been disseminated in Slvt. Extr. Ion Exch.
June 2023-Congratulations to Meagan for successfully defending her M.S. thesis!
November 2022-Congratulations to Fortune for successfully defending her M.S. thesis and for beginning her first professional position at Eli Lilly and Co., Indianapolis, IN (Jan. ’23)!
November 2022-Congratulations to Dr. Carrick for receiving a Henry Dreyfus Teacher-Scholar Award. www.dreyfus.org
May 2022-Congratulations to Connor for earning his B.S. in Mathematics
August 2021-Mariah matriculates to the Ph.D. program in Chemistry at Boston College and joins research group of Prof. P. Zhang
August 2021-Zac begins his first professional position in the medicinal chemistry division at Novartis Institutes for Biomedical Research, Boston, MA
June 2021-Congratulations to Mariah for successfully defending her M.S. thesis!
June 2021-Congratulations to Zac for successfully defending his M.S. thesis!
May 2021-Congratulations to Gabrielle for earning her B.S. in Chemical Engineering and beginning her professional career at Eastman Chemical, Kingsport, TN

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