Chemistry

Jesse D. Carrick, Ph.D.

Professor
Department of Chemistry
TN Tech University
Campus Box 5055
803 Stadium Dr.
Lab Science Commons, Rm 3304
Cookeville, TN 38505-0001

P:  (931) 372-6199
E:  jcarrick@tntech.edu

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Education:

• A.S. 2000 Motlow State Community College

• B.S. 2002 Middle TN State University (Prof. Norma K. Dunlap)

• M.S. 2005 Indiana University-Bloomington (Prof. David R. Williams)

• Ph.D. 2008 The University of Alabama (Prof. Michael P. Jennings)

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Dr. Carrick's Curriculum Vitae 

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Bio:

Jesse D. Carrick was born in Murfreesboro, TN and spent his formative years on the family farm near Shelbyville, TN.  He attended Cascade High School, Wartrace, TN and graduated with an Honors diploma in 1998. Carrick attended Motlow State Community College and graduated with an A.S. in 2000. He was introduced to the art and science of chemical synthesis as an undergraduate student at Middle Tennessee State University with Prof. Norma K. Dunlap earning an ACS-certified B.S. in chemistry in 2002. Carrick then relocated to Indiana University, Bloomington where he contributed to efforts toward the total synthesis of the marine natural product amphidinolide C in the laboratory of Prof. David R. Williams, earning his M.S. in 2005.  Carrick completed his doctoral work at The University of Alabama in 2008 under the direction of Prof. Michael P. Jennings where he accomplished a formal synthesis of the marine natural product (−)-clavosolide a. 

He obtained professional experience as a Senior Research Scientist in chemical development (process) at Albany Molecular Research Inc., in Albany, NY from 2009-10 and returned to academia as a Visiting Assistant Professor of Chemistry at Union College, Schenectady, NY (2010-11) where he initiated research in the area of organic synthesis with undergraduates. 

Carrick accepted a tenure-track appointment as an Assistant Professor in the Department of Chemistry at Tennessee Technological University, Cookeville, TN in 2011, was tenured and promoted to Associate Professor in 2016, and promoted to Professor in 2021. Research in the Carrick group is currently focused in two distinct, but complementary student-training areas: Synthesis of heterocyclic complexants for chemoselective minor actinide separations, and  Total synthesis of biologically relevant natural products. 

When not in the lab he enjoys studying American history, fishing, gardening, and drag racing.

31.  Fletcher, L. S.; Tedder, M. L.; Olayiwola, S. O.; Carrick, J. D.* A Hydrolytically Stable Complexant for Minor An Separation from Ln in Process Relevant Diluents.  Chemical Communications 2024, 60, 5642–5645. View Article

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30.  Edirin, O. J.; Carrick, J. D.* Synthesis of Fused [1,2,3]-Triazoloheteroarenes via Intramolecular Azo Annulation of N-Tosylhydrazones Catalyzed by 1,8-Diazabicyclo[5.4.0]undec-7-ene.  Journal of Organic Chemistry 2024, 89, 7201–7209.  View Article

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29.  Tedder, M. L.; Carrick, J. D.* A Synthetic Strategy for the Preparation of Alkoxy-Functionalized Bis-1,2,4-triazinyl-pyridines.  Journal of Heterocyclic Chemistry 2024, Early View.   View Article

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28.  Fletcher, L. S.; Tedder, M. L.; Olayiwola, S. O.; Joyner, N. A.; Mason, M. M.; Oliver, A. G.; Ensor, D. D.; Dixon, D. A.; Carrick, J. D.* Next Generation 3,3’-AlkoxyBTPs as Complexants for Minor Actinide Separation from Lanthanides:  A Comprehensive Separations, Spectroscopic, and DFT Study.  Inorganic Chemistry 2024, 63, 4819–4827. View Article

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27.  Agyei, E. A.; Carrick, J. D.* Synthetic Approach to the Construction of Unsymmetric Pyridyl-1,2,4-Triazine Complexants.  Tetrahedron 2024, 155, 133872.  DOI: View Article

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26. Fletcher, L. S.; Tedder, M. L.; Olayiwola, S. O.; Ensor, D. D.; Carrick, J. D.* Separation of 241Am3+ from 154Eu3+ from Simulated Spent Nuclear Fuel in Trifluoromethylphenyl Sulfone using 3,3’-butyloxy-bis-1,2,4-triazinyl-2,6-pyridine as a Potent Receptor. Solvent Extraction and Ion Exchange 2024, 42, 105–117.  View Article

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25. Agyei, E. A. and Carrick, J. D.* Metal-Free, Oxidative Condensation of Heteroaryl- and Aryl Carbaldehydes towards Functionalized Carbonitriles.  Chemistry Select 2023, 8, e202300866. View Article

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24. Xiao, Z.; Liu, J.; Liu, K.; Petridis, L.; Cai, C.; Cao, L.; Wang, G.; Chin, A.-L.; Cleveland, J. W.; Ikedionwu, M. O.; Carrick, J. D.; Smith, J. C.; Quarles, L. D.*  Small Molecule FGF23 Inhibitors Increase Serum Phosphate and Improve Skeletal Abnormalities in Hyp Mice.  Molecular Pharmacology 2022, 101, 408–421.  View Article

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23. Tedder, M. L.; Dzeagu, F. O.; Mason, M. M.; Dixon, D. A.; Carrick, J. D.*  Microwave-Assisted C-H Oxidation of Methylpyridylheteroarenes via a Kornblum-type Reaction. Tetrahedron 2022, 116, 132805,  DOI:  View Article  

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22. Gulledge, Z. Z.; Duda, D. P.; Dixon, D. A.; Carrick, J. D.*  Microwave-Assisted, Metal- and Azide-Free Synthesis of Functionalized Heteroaryl-1,2,3-triazoles via Oxidative Cyclization of N-Tosylhydrazones and Anilines.  Journal of Organic Chemistry 2022, 87, 12632–12643,  View Article

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21.  Gulledge, Z. Z.; Pinson, C. C.; Stovall, A. M.; Dzeagu, F. O.; Carrick, J. D.*  Chemoselective, Osmium-Free, Dihydroxylation / Oxidative Cleavage of Heteroaryl Isoprenes by a Contemporary Malaprade Reaction.  Organic and Biomolecular Chemistry 2022, 20, 7916–7922.  View Article

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20.  Dzeagu, F. O.  and Carrick, J. D.*  Synthetic Access to Unsymmetric 1,3,4-oxadiazolyl Complexant Scaffolds via Intramolecular Oxidative Annulation of Arylhydrazones with Heteroaryl Carbaldehydes.  Journal of Organic Chemistry 2022, ASAP, 12/27/22  View Article

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19.  Prediction of An(III)/Ln(III) Separation by 1,2,4-Triazinylpyridine Derivatives Marcos M. Mason, Caris Smith, Monica Vasiliu, Jesse D. Carrick, and David A. Dixon The Journal of Physical Chemistry A 2021 125 (30), 6529-6542 View Article

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18.  Downs, R. P.; Xiao, Z.; Ikedionwu, M. O.; Cleveland, J. W.; Chin, A.-L.; Cafferty, A. E.; Quarles, L. D.; Carrick, J. D.*  Design and development of FGF-23 antagonists:  Definition of the pharmacophore and initial structure-activity relationships probed by synthetic analogues.  Bioorganic and Medicinal Chemistry 2021, 29, 115877.  DOI: 10.1016/j.bmc.2020.115877. View article.

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17.  Waters, G. D.; Carrick, J. D. "Convergent access to bis-1,2,4-triazinyl-2,2’-bipyridines (BTBPs) and 2,2’-bipyridines via a Pd-catalyzed Ullman-type reaction." RSC Advances 2020, 10, 10807–10815. View Article

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16.  Gulledge, Z. Z.; Carrick, J. D.* Chemoselective BOC-deprotection of functionalized heteroarenes using an addition/elimination strategy.  European Journal of Organic Chemistry, 2020, 12, 1817–1822.  View Article 

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15.  Gulledge, Z. Z.; Tedder, M. L.; Lyons, K. R.; Carrick, J. D.* Synthesis of tridentate indolyl pyridinyl [1,2,4] triazine Lewis basic complexants via Pd-catalyzed Suzuki-Miyaura cross-coupling.  ACS Omega, 2019, 4, 18855–18866.  View Article

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14.  Veerakanellore, G. B.; Smith, C. M.; Vasiliu, M.; Oliver, A. G.; Dixon, D. A.; Carrick, J. D.*  Synthesis of 1H-pyrazol-5-yl-pyridin-2-yl-[1,2,4]triazinyl soft-Lewis basic complexants via metal and oxidant free [3+2] dipolar cycloaddition of terminal ethynyl pyridines with tosylhydrazides.  Journal of Organic Chemistry 2019, 84, 14558–14570.  View Article

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13.  Chaudhuri, S.; Carrick, J. D.* Synthetic access to functionalized dipolarophiles of Lewis Basic Complexant Scaffolds through Sonogashira Cross-Coupling.  Journal of Organic Chemistry 2018, 83, 10261−10271, View Article

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12.  Smith, C. D.; Downs, R. P.; Carrick, J. D.; Dietz, M. L.* Determination of extractant solubility in ionic liquids by thermogravimetric analysis. Solvent Extraction and Ion Exchange 2018, 36, 304−314.  View Article

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11.  Lambert, A. E.; Carrick, J. D.* Diversification of 6-bromo-2-substituted pyridine derivatives via Suzuki-Miyaura cross-coupling.  Journal of Heterocyclic Chemistry 2018, 55, 1232−1239, View Article

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10.  Hill, T. G.; Chin, A.-L.; Tai, S.; Carrick, J. D.; Ensor, D. D.; Delmau, L. H.  Separation of americium from europium using 3,3’-dimethoxy-phenyl-bis-1,2,4-triazinyl-2,6-pyridine. Separation Science and Technology 2018, 53, 1848−1855, View Article

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9.  Tevepaugh, K. N.; Coonce, J. G.; Tai, S.; Delmau, L. H.; Carrick, J. D.; Ensor, D. D.  Chromatographic separation of americium from europium using bis-2,6-(5,6,7,8-tetrahydro-5,9,9-trimethyl-5,8-methano-1,2,4-benzotriazin-3-yl) pyridine.  Journal of Radioanalytical and Nuclear Chemistry 2017, 314(1), 371−376.  View Article

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8.  Cleveland, J. W.; Carrick, J. D.* Pd-catalyzed amination of functionalized 6-bromo-pyridinyl-1,2,4-triazine  complexant scaffolds.  European Journal of Organic Chemistry 2017, 2017(23) 3318−3327.  View Article

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7.  Downs, R. P.; Chin, A.-L.; Dean, K. M.; Carrick, J. D.* Synthesis of functionalized hemi-1,2,4-triazinyl-[2,2’]-bipyridines via telescoped condensation of [2,2']-bipyridinyl-6-carbonitrile. Journal of Heterocyclic Chemistry 2017, 54(6), 3008−3014.  View Article

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6.  Xiao, Z. S.; Riccardi, D.; Velazquez, H. A.; Chin, A.-L.; Yates, C. R.; Carrick, J. D.; Smith, J. C.; Baudry, J.; Quarles, L. D. Computationally identified novel chemical compounds that antagonize FGF-23.  Science Signaling 2016, 9(455), ra113-Cover Story.  View Article

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5.  Tai, S.; Marchi, S. V.; Carrick, J. D.* Efficient preparation of pyridinyl-1,2,4-triazines via telescoped condensation with diversely functionalized 1,2-dicarbonyls.  Journal of Heterocyclic Chemistry 2016, 53, 1138−1146.  View Article

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4.  Chin, A.-L.; Carrick, J. D.* Modular approaches to diversified soft Lewis basic complexants through Suzuki-Miyaura cross-coupling of bromoheteroarenes with organotrifluoroborates.  Journal of Organic Chemistry 2016, 81, 1106−1115.  View Article

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3.  Tevepaugh, K. N.; Carrick, J. D.; Tai, S.; Coonce, J. G.; Delmau, L. H.; Ensor, D. D.  Separation of americium from europium using camphor-bistriazinyl pyridine.  Solvent Extraction and Ion Exchange 2016, 34, 13−25.  View Article

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2.  Tai. S., Williams, N. J.; Carrick, J. D.*  Synthesis of bis-1,2,4-triazines via telescoped condensation of [1,10]-phenanthroline-2,9-dicarbonitrile with aromatic 1,2-dicarbonyls.  Journal of Heterocyclic Chemistry 2016, 53, 307−312.  View Article

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1.  Tai, S.; Marchi, S. V.; Dover, E. J.; Carrick, J. D.* Pd-catalyzed diamination of dibromo-1,2,4-triazinyl complexant scaffolds.  Journal of Organic Chemistry 2015, 80, 6275−6282.  View Article

Current Group Members

• Thilakarathne, Lakshi M., EVS Ph.D. student, lmthilakar42@tntech.edu,  LSC 3312

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• Agyei, Eric A.  M.S. student, eaagyei42@tntech.edu, LSC 3312
• Ajibola, Bolade R. M.S. student, bajibola42@tntech.edu, LSC 3312
• Aimiuwu, Emmanuel E., M.S. student, eeaimiuwu42@tntech.edu LSC 3312
• Edirin, Orume M.S. student, ojedirin42@tntech.edu, LSC 3312
• Jonathan, Victor M.S. student, vcjonathan42@tntech.edu, LSC 3312
• Olayiwola, Samiat O. M.S. student, soolayiwol42@tntech.edu, LSC 3312

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• Buchanan, Anna L., B.S. student, albuchanan42@tntech.edu, LSC 3312
• Hudak, C. Blake B.S. student, cbhudak42@tntech.edu, LSC 3312
• Wood, Shayla G., B.S. student, sgwood42@tntech.edu, LSC 3312

Teaching:

• CHEM 6210 Advanced Organic Chemistry

• CHEM 3010 Organic Chemistry I

• CHEM 3020 Organic Chemistry II

Research Opportunities:

The Carrick group currently has open positions for postdoctoral, EVS Ph.D., M.S., and B.S. students for the 2024-2025 academic year.  Students with research interests in separation science broadly defined, as well as analytical, inorganic, and organic chemistry are particularly encouraged to contact Dr. Carrick at jcarrick@tntech.edu for additional information.